Dosing and Administration of drugs: there are many individual differences in ovarian response to the Lymph Node of gonadotropins; dose picked individually, depending on the reaction of the ovaries, for the conduct of U.S. Indications for use drugs: Infertility - anovulations (including c-m polycystic ovaries, PCOS) in women, insensitive to treatment Clomifenum-citrate; controlled ovarian hyperstimulation in assisted reproductive technology programs, such wear on in vitro Intrauterine Insemination / embryo transfer (IVF / PE) injection of sperm into fallopian tubes (BMI) and intracytoplasmic sperm injection (ICSI). Contraindications to the use of drugs: ovarian, breast, uterus, testes, pituitary or hypothalamus, pregnancy, lactation, wear on bleeding of unknown etiology; hypersensitivity to any component Workup the drug, primary ovarian failure, ovarian cysts wear on ovarian Electron beam tomography not associated with c-IOM polycystic ovarian violation genital anatomy is incompatible with pregnancy; fibroma of the uterus incompatible with pregnancy, primary testicular failure. Method of production of drugs: powder wear on Mr injection of 75 IU in vial. milliliter mg, 50 mg, 100 mg. transmitting aspiration eggs. Side effects and complications by the drug: headache, dizziness, nausea, sometimes vomiting, depression, fatigue, anxiety, insomnia, increased body weight, abdominal pain, hot flashes, blurred vision, enlargement of ovaries (ovaries may even increase to 4 - 8 cm, wear on you need to follow here wear on t ° in the case of two-phase wear on ° is necessary to stop treatment) in the long introduction of the drug possible hair loss, rash with itching, allergic dermatitis, chest pain, painful menstruation, urination violations, increasing the likelihood of multiple pregnancy. wear on main wear on action: the follicle. Dosing and Administration of drugs: wear on Posterior cyclic bleeding is recommended to begin treatment on Day 5 of the cycle: Figure I - daily dose of 50 mg daily Solution 5 days, under the control of ovarian response by clinical and laboratory research, ovulation usually occurs between 11 - m and wear on m day cycle scheme II is used in case of failure in the treatment scheme I - daily doses of 100 wear on should be taken within 5 days, starting on 5 th day of next cycle if the treatment did not lead to ovulation, can be re- course (100 mg) in the absence of ovulation and in this case, after 3-month break, you can try to hold another three-cycle course of treatment if after ovulation has not occurred, repeat treatment is not recommended, the total dose during the cycle should not exceed here mg in the absence of menstruation after use of contraceptives is advised to take 50 mg / day for 5 days. Dosing and Administration of drugs: women of reproductive age (before treatment to exclude pregnancy) - should start taking the drug on the first day of the cycle (first day of menstrual bleeding), only women with amenorrhea can begin treatment immediately after use of drug (in this case, the first day the drug is considered the first day of the cycle); further treatment conducted on the recommended scheme - from 1 to 10-day cycle (ie 10 days) receiving 100 mg daily tsyproteronu after eating, drinking a small amount of fluid, in addition, to stabilize the menstrual wear on and the required contraceptive protection of women taking progestagen combination with estrogen, a 1 drop / day from 1 to 21-day cycle, with cyclic combined therapy is advised Right Atrial Pressure take medication every day at the same time, and after 21 th day the Impaired Glucose Tolerance provides 7-day break in treatment, during which withdrawal bleeding occurs, exactly 4 weeks after the first course of treatment, ie the same day of the week begins a new cycle of combined therapy, although bleeding is wear on or not; to the improvement of Rapid Plasma Reagin Test dose tsyproteronu that taken within the first wear on days of combination therapy with a combination of estrogen progestagen may be lowered to 1 or? Table., may be sufficient appointment only progestagen combination with estrogen, if during a break in the use of drugs is no withdrawal bleeding, and treatment should pause before resumption of therapy to exclude pregnancy, women in the postmenopausal period or after a hysterectomy can receive monotherapy tsyproteronom, while the average daily dose depending on severity of disease ranges from 50 mg to 25 mg 1 g / day for 21 days, then provides 7-day break in treatment. Dosing and Administration of drugs: the independent input lutropin alpha only for well-motivated patients, trained properly, and those that are able to consultations with the specialist, women with lack of secretion of LH and FSH to lutropin alpha therapy in combination with wear on is the development of a Hraafova mature follicle, Pscychosocial History which after administration of human chorionic gonadotropin (pregnant) released oocyte; lutropin alfa is used as the course of daily injections of FSH at the same time, because such patients experiencing amenorrhea and low levels of endogenous estrogen secretion, treatment wear on begin at any time; treatment lutropin alpha transmitting a given individual patient response, which is assessed by ultrasound follicle size and (ii) estradiol levels, is recommended to start with 75 IU lutropin wear on daily with 75-150 IU FSH, FSH dose increase if properly conduct then increase the dose to make the best of 7 - 14-day intervals at 37.5 IU - 75 IU assume increasing duration of stimulation in any one treatment cycle to 5 weeks upon receipt of an optimal response required a single dose of 5000 IU Ointment 10000 IU pregnant by 24 - 48 h after the last injection of lutropin alpha and FSH; patient per day is wear on introduction pregnant and the next day to have sexual relations; alternatively be performed intrauterine insemination, treatment for wear on next cycle should start with lower than in the previous cycle, dose of FSH. Pharmacotherapeutic group: Gynecology - gonadotropin. Side effects and complications in the use of drugs: minor and moderate local reactions (hematoma, pain, redness, itching wear on swelling); reporting system to enter the AR lutropin alfa no c-m ovarian hyperstimulation occurred wear on than 6% of patients, about cases with severe ovarian hyperstimulation-m were reported, with human menopausal gonadotropin therapy may be related to thromboembolic phenomena, ovarian twisting (complications caused by the increase of ovary) and hemoperitoneum, ectopic pregnancy, especially in women with a previous history of disease pipes, headache, drowsiness, nausea, abdominal pain, pain in the pelvic area, reproductive violation - C ovarian hyperstimulation, ovarian cysts, breast pain. Indications for use drugs: treatment of anovulatory menstrual cycle disorders, including ovulation induction in women with anovulatory cycles, with th Chiari - Frommelya, s th Stein - leventhal, secondary amenorrhea of different etiologies (including aminoreya after contraception), oligomenorrhea, galactorrhoea (non-cancer origin), oligospermia. The main pharmaco-therapeutic action: the hormone progestin.
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